Adsorption and controlled release of Diclofenac using porous Vaterite BOMPAR Quentin, COUMES Aurelien, DOMENECH Antoine, EL KHADIRI Obayd allah, MLANAO Alialdini, PALGOV Gleb Supervisor : Pr. HORNEBECQ Virginie Master Nanoscience and Nanotechnology -...
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Adsorption and controlled release of Diclofenac using porous Vaterite BOMPAR Quentin, COUMES Aurelien, DOMENECH Antoine, EL KHADIRI Obayd allah, MLANAO Alialdini, PALGOV Gleb Supervisor : Pr. HORNEBECQ Virginie Master Nanoscience and Nanotechnology - Materials Engineering and Nanotechnology Context Vaterite: A porous matrix Pores averaging around 30 nm Vaterite fully loaded with Diclofenac Vaterite-to-calcite transformation Drug adsorption within Phase change induced by the pores and on the contact with an aqueous surface medium 1 µm Diclofenac 1 µm μ-CaCO₃ / metastable phase Spherical nanometric aggregates Drug release induced by loss of porosity Experiments Synthesis of Vaterite via chemical precipitation First step: Synthesis 1)- Rapid precipitation 2)- Filtration 3)- Thermal Dehydration Na2CO3 + CaCl2 Water CaCO3 + Na2Cl2 Second step: Adsorption Schematic illustration of the Diclofenac adsorption protocol on Vaterite Vaterite We proceeded to have the drug adsorbed in Vaterite at di
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