■■FURTHER READING polyps by age 50. The rate steadily rises as people age, and as many as 653 Ben-Aharon I et al: Early-onset cancer in the gastrointestinal tract is 50% of 70-year-old people will have adenomatous polyps. Less than 5% on the rise-evidence...
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■■FURTHER READING polyps by age 50. The rate steadily rises as people age, and as many as 653 Ben-Aharon I et al: Early-onset cancer in the gastrointestinal tract is 50% of 70-year-old people will have adenomatous polyps. Less than 5% on the rise-evidence and implications. Cancer Discov 13:538, 2023. of adenomatous polyps are expected to progress to an adenocarcinoma. Cancer Genome Atlas Research Network: Comprehensive molec- The vast majority of adenomatous polyps are asymptomatic and do not ular characterization of gastric adenocarcinoma. Nature 513:202, bleed. The risk of progression to cancer is associated with size of the 2014. polyp and the histology. Villous adenomas develop into cancer three- Cancer Genome Atlas Research Network et al: Integrated fold more often than tubular adenomas. genomic characterization of oesophageal carcinoma. Nature 541:169, 2017. ■■MOLECULAR PATHOGENESIS Choi IJ et al: Helicobacter pylori and prevention of gastric cancer. N The majority of colon cance
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