Two Fold Serial Dilution A Simple Method To 27

Viewpoint Cosmetic Two-fold Serial Dilution: A Simple Method to Adjust Thickness of Injectable Poly-D,L-lactic Acid Chuan-Yuan Lin, MD*,†; Svetlana Pervykh, MD‡; Victoria Lysikova, MD§; Natalia Markova, MD¶; Jui-Yu Lin, MD† I njectable poly-D,L-lactic acid... More

Viewpoint Cosmetic Two-fold Serial Dilution: A Simple Method to Adjust Thickness of Injectable Poly-D,L-lactic Acid Chuan-Yuan Lin, MD*,†; Svetlana Pervykh, MD‡; Victoria Lysikova, MD§; Natalia Markova, MD¶; Jui-Yu Lin, MD† I njectable poly-D,L-lactic acid (PDLLA) is a relatively new subdermal collagen-stimulating filler (AestheFill; REGEN Biotech, Seoul, South Korea) containing PDLLA amount of this suspension by the same amount of SWFI. The density halves and it becomes a thick suspension. Then we repeat the same procedures described above. microspheres and carboxymethyl cellulose. It is supplied We can obtain thin and finally super-thin suspensions. as lumps of lyophilized powder in vials. Reconstituting “D1.5-D3-D6-D12” is the most common density combina- injectable PDLLA with sterile water for injection (SWFI) to tion we have been using for 2 years (Fig. 2). There are form a homogeneous suspension is needed before injec- many other density combinations such as “D1.7-D3.4- tion.1–5 Less