AMERICAN Journal of Epidemiology Formerly AMERICAN JOURNAL OF HYGIENE VOL. 99 JUNE, 1974 NO. 6 Reviews and Commentary SAMPLE SIZE REQUIREMENTS IN COHORT AND CASE-CONTROL STUDIES OF DISEASE JAMES J. SCHLESSELMAN1 INTRODUCTION among the non-exposed and the...
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AMERICAN Journal of Epidemiology Formerly AMERICAN JOURNAL OF HYGIENE VOL. 99 JUNE, 1974 NO. 6 Reviews and Commentary SAMPLE SIZE REQUIREMENTS IN COHORT AND CASE-CONTROL STUDIES OF DISEASE JAMES J. SCHLESSELMAN1 INTRODUCTION among the non-exposed and the relative The connection between sample size re- risk of disease that one regards as im- quirements in cohort and case-control portant to detect. The sample size re- studies does not seem to be generally ap- quirement for a case-control study, how- preciated. The writer's opinion is based on ever, depends on the prevalence of ex- recent experience in the review of a number posure to the factors) and the relative of research proposals submitted to the risk of disease that one regards as im- National Institutes of Health. Of all the portant to detect. proposals which advocated the case-control To help fix ideas and simplify exposi- design and which addressed the issue of tion, suppose one is interested in studying sample size, not one pre
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