Contact me :
Ms. Nancy
Wickr me: nancyj21
Email: nancy@whlwax.com
WhatsApp / Signal / Skype / Telegram:
+8615271919527
Product Description
Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50 = 1.2 nM).1 It is selective for PDE5 over...
More
Contact me :
Ms. Nancy
Wickr me: nancyj21
Email: nancy@whlwax.com
WhatsApp / Signal / Skype / Telegram:
+8615271919527
Product Description
Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50 = 1.2 nM).1 It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury.2 It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice.3 Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.
Less
