Illicitly Manufactured Fentanyl–Involved Overdose Deaths with Detected Xylazine — United States, January 2019–June 2022

Morbidity and Mortality Weekly Report Illicitly Manufactured Fentanyl–Involved Overdose Deaths with Detected Xylazine — United States, January 2019–June 2022 Mbabazi Kariisa, PhD1; Julie O’Donnell, PhD1; Sagar Kumar, MPH1; Christine L. Mattson, PhD1; Bruce... More

Morbidity and Mortality Weekly Report Illicitly Manufactured Fentanyl–Involved Overdose Deaths with Detected Xylazine — United States, January 2019–June 2022 Mbabazi Kariisa, PhD1; Julie O’Donnell, PhD1; Sagar Kumar, MPH1; Christine L. Mattson, PhD1; Bruce A. Goldberger, PhD2 In 2022, provisional data indicated that more than two thirds coroner reports (including information about circumstances (68%) of the reported 107,081 drug overdose deaths in the of the overdose from scene evidence and witness reports), and United States involved synthetic opioids other than metha- toxicology reports. Monthly counts of IMF-involved deaths¶ done, principally illicitly manufactured fentanyls (IMFs) (1). with xylazine detected and co-involved as a cause of death, and Xylazine, a nonopioid sedative not approved for human use proportions of IMF-involved deaths with xylazine detected and with no known antidote, has been increasingly detected in were examined in 21 jurisdictions** for January 2019–June I Less