Payload of Antibody-drug Conjugates (ADCs) — MMAE and MMAF Brief Introduction

Auristatin is a dolastatin 10-based auristatin analog. Dolastatin 10 was initially isolated from the sea hare Dolabella auricularia at a vanishingly low yield (~ 1 mg from each 100 kg). It is a unique linear pentapeptide comprising of several unusual amino... More

Auristatin is a dolastatin 10-based auristatin analog. Dolastatin 10 was initially isolated from the sea hare Dolabella auricularia at a vanishingly low yield (~ 1 mg from each 100 kg). It is a unique linear pentapeptide comprising of several unusual amino acids Less