Glykokalyx & Volumentherapie Die endotheliale Glykokalyx: Ein Key-Player in der Volumentherapie Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang...
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Glykokalyx & Volumentherapie Die endotheliale Glykokalyx: Ein Key-Player in der Volumentherapie Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, et al. Crit Care 2019; 23:259 BACKGROUND: Intravenous fluids, an essential component of aran sulfate was elevated in septic shock patients (118 [IQR, 113-341] sepsis resuscitation, may paradoxically worsen outcomes by exacer- ng/ml 6 h after presentation) compared to non-infected controls (61 bating endothelial injury. Preclinical models suggest that fluid resusci- [45-79] ng/ml), as well as in a second cohort of sepsis patients (283 tation degrades the endothelial glycocalyx, a heparan sulfate-enriched [155-584] ng/ml) at emergency department presentation) compared structure necessary for vascular homeostasis. We hypothesized that to controls (177 [144-262] ng/ml). In the larger sepsis cohort, heparan en
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