Colossolactone H, a New Ganoderma Triterpenoid Exhibits Cytotoxicity and Potentiates Drug Efficacy of Gefitinib in Lung Cancer

Fitoterapia 114 (2016) 81–91 Contents lists available at ScienceDirect Fitoterapia journal homepage: www.elsevier.com/locate/fitote Colossolactone H, a new Ganoderma triterpenoid exhibits cytotoxicity and potentiates drug efficacy of gefitinib in lung cancer... More

Fitoterapia 114 (2016) 81–91 Contents lists available at ScienceDirect Fitoterapia journal homepage: www.elsevier.com/locate/fitote Colossolactone H, a new Ganoderma triterpenoid exhibits cytotoxicity and potentiates drug efficacy of gefitinib in lung cancer Su-Yu Chen a, Chao-Lin Chang a,b, Teng-Hai Chen c, Ya-Wen Chang a,⁎, Shwu-Bin Lin a,c,⁎⁎ a Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China b Food Industry Research and Development Institute, Hsinchu, Taiwan, Republic of China c Trineo Biotechnology Co., LTD, New Taipei City, Taiwan, Republic of China a r t i c l e i n f o a b s t r a c t Article history: Three pentacyclic triterpene dilactones were isolated from the fruiting bodies of Ganoderma colossum, a medici- Received 15 June 2016 nal mushroom. Colossolactone H (colo H) as a new compound and the most cytotoxic among the isolates was Received in revised form 20 August 2016 stu Less